DIPG (Diffuse Intrinsic Pontine Glioma) and DMG (Diffuse Midline Glioma) are often categorized together but can have different treatments that can lead to slightly different prognosis paths. Still, much of the science, the research, foundational funding and data for both types of brain tumors are grouped under DIPG, mainly because historically much of the work researching DIPG since around 2012 led to the reclassification and current definitions of DMG.

DIPG is a type of brain tumor found in an area of the brainstem known as the pons. The name diffuse intrinsic pontine glioma describes how the tumor grows, where it is found, and what kinds of cells give rise to the tumor. Diagnoses of DIPG are typically made through an MRI or radiological exam. Diffuse means that the tumor is not well-contained – it grows out into other tissue so that cancer cells mix with healthy cells. Intrinsic simply means 'in', referring to the point or origin. Pontine indicates that the tumor is found in a part of the brainstem called the pons. The pons is responsible for a number of important bodily functions, like breathing, sleeping, bladder control, and balance. Glioma is a general term for tumors originating from glial cells. Glial cells are found throughout the brain. They make up the white matter of the brain that surrounds and supports the neurons (neurons are cells that carry messages in the brain). The lowest grade consistent with a DIPG is a grade 2 tumor, but many DIPG tumors will be grade 3 or 4 (the most-aggressive, fastest-growing grades).

Certain factors may lead to improved survival prognosis with those diagnosed with DIPG. They include those patients diagnosed before the age of 3 or after the age of 10, those patients with few symptoms prior to diagnosis and those patients with limited to no growth beyond the pons.

Ultimately some DIPG tumors reviewed by MRI may be termed as “atypical” possibly leading to other diagnosis methodologies such as a biopsy to determine if other treatment options exist. For this reason it is strongly recommended that patients diagnosed with DIPG seek enrollment in the International DIPG/DMG Registry or the SIOPe DIPG Registry so that the MRI may be centrally reviewed by radiologists with strong experience with these types of tumors.

DMG, on the other hand, is a clarified diagnosis of a DIPG through a biopsy and more recently through blood biopsy methods. An astrocytoma located along the midline of the brain, it can also be found in midline structures like the spinal cord or thalamus. Often these tumors start as “atypical” DIPG and are formally diagnosed as DMG. Still aggressive, they are often classified as a grade 4 tumor and tend to spread to neighboring tissue.

If a user currently has a DMG installation of Teams and wants to replace it with the PKG installation, the user should: Exit the Teams app. Uninstall the Teams app. Install the PKG file. IT admins can use managed deployment of Teams to distribute the installation files to all Macs in their organization, such as Jamf Pro. VS Code; Edge Code CC; Visual Studio; PhpStorm; Adobe Dreamweaver; JSON Syntax. JSON data is written in key/value pairs. The key and value are separated by a colon(:) in the middle with the key on the left and the value on the right. Different key/value pairs are separated by a comma(,). I plan to mass deploy a piece of software, (Mathematica), but the.dmg includes a.app file instead of a.pkg file which is what I need. The guide below shows how to do it with Google Chrome, but. Oct 11, 2010 DMGConverter is a Disk Image (.dmg.cdr.iso) creation and conversion tool which is simple and easy to use.

Starting as early as 2012, due to the surgical advancement of biopsy methods, it was discovered that DMGs also have a specific mutation in the H3F3A gene and are commonly referred to as H3K27 mutant. As these have received genomic analysis through leading registries such as the International DIPG/DMG Registry and the SIOPe DIPG Registry, genetic marker identification has led to the discovery of certain drugs and treatments that may be applicable. This has also led to the findings reported in 2018 in the Journal of Clinical Oncology (https://thecurestartsnow.org/impact/news/characteristics-of-long-term-survivors-of-dipg/) detailing a slightly higher chance of improved prognosis with those patients that present the H3K27 mutation.

While a World Health Organization reclassification of these astrocytomas categorizes DIPG as a subgroup of DMG, most researchers and foundations tend to regard DMGs as a parallel group to DIPG in that the diagnosis of a patient starts with DIPG and then is later identified as a DMG after biopsy or blood biopsy methods.

Learn more about the diagnosis and imaging of DIPG

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You can use this guide to get practical information on how to find and install the latest Java, understand the differences between Java distributions (AdoptOpenJdk, OpenJDK, OracleJDK etc.), as well as get an overview of Java language features, including version Java versions 8-16.

Practical Information

First, let’s have a look at some common, practical questions that people have when trying to choose the right Java version for their project.

TL;DR I only want a download link and know about everything else. Where should I go?

Go to the AdoptOpenJDK site, chose the latest Java version, download and install it. Then come back to this guide to maybe still learn a thing or two about Java versions.

What is the latest Java version?

As of March 2021, Java 16 is the latest released Java version.

What Java version should I use?

Newer Java versions now follow every 6 months. Hence, Java 17 is scheduled for September 2021, Java 18 for Marc 2022 and so on. In the past, Java release cycles were much longer, up to 3-5 years. This graphic demonstrates that:

With that many new versions coming out, there’s basically these real-world(™) usage scenarios:

Legacy projects in companies are often stuck with using Java 8 (see Why are companies still stuck with Java 8?) . Hence you will be forced to use Java 8 as well.
Some legacy projects are even stuck on Java 1.5 (released 2004) or 1.6 (released 2006) - sorry, pals!
If you are making sure to use the very latest IDEs, frameworks and build tools and starting a greenfield project, you can, without hesitation, use Java 11 (LTS) or even the latest Java 16.
There’s the special field of Android development, where the Java version is basically stuck at Java 7, with a specific set of Java 8 features available. Or you switch to using the Kotlin programming language.

Why are companies still stuck with Java 8?

There’s a mix of different reasons companies are still stuck with Java 8. To name a few:

Build tools (Maven, Gradle etc.) and some libraries initially had bugs with versions Java versions > 8 and needed updates. Even today, with e.g. Java >=9, certain build tools print out 'reflective access'-warnings when building Java projects, which simply 'feels not ready', even though the builds are fine.
Up until Java 8 you were pretty much using Oracle’s JDK builds and you did not have to care about licensing. Oracle changed the licensing scheme In 2019, though, which led the internet go crazy with a ton of articles saying 'Java is not free anymore' - and a fair amount of confusion followed. This is however not really an issue, which you’ll learn about in the Java Distributions section of this guide.
Some companies have policies to only use LTS versions and rely on their OS vendors to provide them these builds, which takes time.

To sum up: you have a mix of practical issues (upgrading your tools, libraries, frameworks) and political issues.

Why are some Java versions, like 8 also called 1.8?

Java versions before 9 simply had a different naming scheme. So, Java 8 can also be called 1.8, Java 5 can be called 1.5 etc. When you issued the 'java -version' command, with these versions you got output like this:

Dmg Vs Pkg